Tetrabromodiphenyl Ether (BDE 47) Evokes Estrogenicity and Calbindin-D9k Expression through an Estrogen Receptor-Mediated Pathway in the Uterus of Immature Rats
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چکیده
منابع مشابه
An ADME Study with 2,2',4,4',-Tetrabromodiphenyl ether (BDE-47) in Chickens
Polybrominated diphenyl ethers (PBDEs) are synthesized in large quantities and are used as flame retardants in textiles and electronic equipment, especially in computer circuit boards. Due to their structural similarity to polychlorinated dibenzo-p-dioxins and biphenyls, their environmental persistence, and a growing database of toxicological effects, this class of compounds has become a new en...
متن کاملCalbindin-D9k gene expression during the perinatal period in the rat: correlation to estrogen receptor expression in uterus.
Calbindin-D9k (CaBP-9k) is a cytosolic calcium binding protein mainly expressed in duodenum, placenta and uterus. The gene encoding the rat CaBP-9k is subject to tissue specific induction by 1,25 dihydroxyvitamin D3 (intestine) and estradiol (E2) (uterus). Control of placental expression remains unknown. The expression of CaBP-9k mRNA during the perinatal period was studied (pregnancy day 21 (P...
متن کاملExpression of calbindin-D9k in the early pregnant rat uterus: effects of RU 486 and correlation to estrogen receptor mRNA.
Calbindin-D9k (CaBP-9k) is a calcium binding protein expressed at high levels in the rat uterus. The CaBP-9k gene carries an estrogen response element which is involved in the steroid hormone regulation of the gene during the estrous cycle and gestation. The present study was aimed at determining expression of the gene during the first half of pregnancy and to assess the role of progesterone (P...
متن کاملUptake and biotransformation of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) in four marine microalgae species
Hydroxylated- and methoxylated- polybrominated diphenyl ethers (OH-PBDEs and MeO-PBDEs) are more toxic than PBDEs and occur widely in the marine environment, and yet their origins remain controversial. In this study, four species of microalgae (Isochrysis galbana, Prorocentrum minimum, Skeletonema grethae and Thalassiosira pseudonana) were exposed to BDE-47, which is synthetic and is the predom...
متن کاملHigh body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breast cancer study and in a reproductive study, respectively. Adipose samples (n =...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2007
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfm051